The purpose of this study was numerical and experimental investigations on the influence of ultrasound on Cr (VI) removal from aqueous solution by adsorption onto activated carbon nanoparticles. The effect of key factors on Cr (VI) elimination like media pH, absorbent mass, initial concentration of Cr (VI) and the location of ultrasound transducers were considered. To perform CFD modeling of ultrasound propagation, the vibrations of 1.7 MHz piezoelectric transducers (PZTs) were defined based on the dynamic mesh model. The experimental results indicated that by pH raising from 2 to 8, Cr (VI) removal efficiency had a decreasing trend and at pH=8, it had the lowest value. The adsorption rate increased by augmentation in the adsorbent mass (AM) due to enhancing its specific surface area. In comparison with using a shaker, the ultrasound showed lower needed contact time for Cr (VI) elimination at identical conditions. In addition, CFD results depicted that the acoustic streams were induced in the direction of ultrasound propagation, which is caused to reach the better mixing and Cr (VI) removal efficiency. Finally, the experimental data were adopted with the Langmuir and Freundlich isotherms. The comparison of these models showed that both models were well suited to experimental findings and the data compatibility with Langmuir model was greater.